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L-cysteine and NAC are generally well-tolerated, but possible side effects include: Nausea Vomiting Diarrhea Headache Abdominal pain Allergic reactions (rare) High doses may impact blood pressure or kidney function in sensitive individuals, so medical supervision is advised for long-term or high-dose use

Rapid weight loss from separately stacked compounds can trigger temporary shedding (telogen effluvium) independent of Klow

Stomach acid and digestive enzymes are designed to break down proteins

Mar Environ Res 52:383395 Morelli E, Mascherpa MC, Scarano G (2005) Biosynthesis of phytochelatins and arsenic accumulation in the marine microalga Phaeodactylum tricornutum in response to arsenate exposure

There are other synthetic peptides that have not been well tested, often because early studies found they were not effective or are potentially toxic